In
high-risk patients, shows how Covid impairs immune activity
Oldest survivor of SARS 2
Why
are older people and people with obscure conditions at risk of a potent
Covid-19?
New
research has identified a possible cause: While these dangerous groups produce
a large number of immune cells known as ‘T-helper cells’, their T-helper cells
show dysfunction. Investigators collected blood samples from 39 Covid-19
patients who consented.
In
these blood samples, they break down immune cells and regenerate them with
fragments of the SARS CoV-2 virus. Investigators then counted the T-helper cells
that had responded to the virus. Finally, they evaluated the possibility of a
link between the number of active T-helper cells and the risk factors for
patients. Indeed, researchers have been able to show a link between the
frequency of viral T-helper cells and the age of patients.
A
similar positive combination was also found in relation to the ‘Co-morbidity
Index’, which measures the severity of 19 different medical conditions. As the
Co-morbidity Index of a patient increases, the number of SARS-CoV-2-specific
helper cells in their blood increases. The team also found, however, that
age-related growth and spinal fitness levels were linked to a decrease in the
number of cells that produced the important messenger molecule.
This
stimulates other parts of the body's response. In patients with risk factors,
some SARS-CoV-2-specific T-cells are no longer effective, the study found. “One
could argue that these T-helper cells slow down in people with dangerous
substances. We believe that this has the potential to impair the body's ability
to respond effectively to pathogens, ”states PD-1 protein, which is known to
act as a 'cell' brake 'in the immune system.
It
controls the immune response to prevent the immune system from invading the
body. Researchers indicate that viral cells help cells produce more PD-1 in
patients with severe disease, than in those with severe symptoms. Given that
PD-1 may be responsible for the immune system of some people who produce a
sufficient amount of messenger material, researchers have suggested that PD-1
be used as a new therapeutic target for patients with severe Covid-19.
"Covid-19 patients may ... benefit from treatments aimed at eliminating
this type of 'immune brake'.
Radiologists
show how chest X-rays can predict Covid-19
Researchers
have found that chest X-rays may help in the early detection of Covid-19. Their
findings were published in Radiology: Cardiothoracic Imaging. Radiologists at
the Louisiana State University Health Sciences Center (LSU Health) in New
Orleans conducted a retrospective study of about 400 people being investigated
for Covid-19 in New Orleans. They reviewed X-rays on patients' chest and RT-PCR
compliant viral tests. Using 19-point imaging patterns, they classified each
X-ray of each chest as features, vague, or abnormal with Covid-19. Radiologists
have found a clear X-ray diagnosis (96.6%) and a high probability of 83.8% of
SARS-CoV-2 infections.
Post-Covid
review in children finds severe heart damage
Multisystem
inflammation in children (MIS-C), believed to be linked to Covid-19, is
damaging to the heart. The heart damage is so severe that some children will
need lifelong attention and intervention. The children did not need to show the
old respiratory symptoms of Covid 19 to develop MIS-C, which is frightening.
Babies may have no symptoms, no one knows they have the disease, and a few
weeks later, they may develop this exaggerated inflammation in the body. The
team reviewed 662 MIS-C cases reported worldwide between January 1 and July 25.
Eleven children died. 90% had an ECG test and 54% had normal results.
The
heart damage included:
Dilation
of coronary blood vessels, a phenomenon also seen in Kawasaki disease.
Depressed
ejection fraction, indicating a reduced ability for the heart to pump oxygen at
blood to tissues.
In
screening for novel coronavirus infections, PCR testing and rapid immune
testing come with limitations. The APCR test, which opens the larynx and
throat, can cause infection if it has already left the nose and throat and
reached the lungs during the test. Antibody tests look for antibodies, but
these appear in the days after infection.
Researchers
at Cambridge University have now conducted a care trial that combines these two
types. They reported it to Cell Reports Medicine. This method was tested in 45
patients. Give them nasal / throat lumps and blood serum. The authors designed
a standard two-part gold test, which may be good for Covid19 to confirm. In the
first phase, SARS-CoV-2 transplant viruses are synthesized with serum from
patients to determine whether the serum contains antibodies. The second part
was a standard PCR test. Using this gold standard, 24 patients had Covid-19. In
total, nucleic acid tests can identify eight patients other than Covid-19, but
when combined with a rapid antibody test, 100% of Covid19 patients are well
identified.
Most common symptoms of Coronavirus
v
Fever
v
Dry cough
v
Tiredness
Less common symptoms of Coronavirus
v
Aches and pains
v
Sore throat
v
Diarrhea
v
Conjunctivitis
v
Headache
v
Loss of taste or smell
v
A rash on skin, or discoloration of fingers or toe
To prevent the spread of
COVID-19:
Clean
your hands often. Use soap and water, or an alcohol-based hand rub.
Maintain
a safe distance from anyone who is coughing or sneezing.
Wear
a mask when physical distancing is not possible.
Don’t
touch your eyes, nose or mouth.
Cover
your nose and mouth with your bent elbow or a tissue when you cough or sneeze.
Stay
home if you feel unwell.
If
you have a fever, cough and difficulty breathing, seek medical attention.
Calling
in advance allows your healthcare provider to quickly direct you to the right
health facility. This protects you, and prevents the spread of viruses and
other infections.
Masks
- Masks can help prevent the spread of the virus from the person wearing the
mask to others. Masks alone do not protect against COVID-19, and should be
combined with physical distancing and hand hygiene. Follow the advice provided
by your local health authority.
Self-care
If you
feel sick you should rest, drink plenty of fluid, and eat nutritious food. Stay
in a separate room from other family members, and use a dedicated bathroom if
possible. Clean and disinfect frequently touched surfaces.
Everyone
should keep a healthy lifestyle at home. Maintain a healthy diet, sleep, stay
active, and make social contact with loved ones through the phone or internet.
Children need extra love and attention from adults during difficult times. Keep
to regular routines and schedules as much as possible.
It is
normal to feel sad, stressed, or confused during a crisis. Talking to people
you trust, such as friends and family, can help. If you feel overwhelmed, talk
to a health worker or counselor.
How It Spreads
The virus
that causes COVID-19 is mainly transmitted through droplets generated when an
infected person coughs, sneezes, or exhales. These droplets are too heavy to
hang in the air, and quickly fall on floors or surfaces.
You can
be infected by breathing in the virus if you are within close proximity of
someone who has COVID-19, or by touching a contaminated surface and then your
eyes, nose or mouth.